Varenicline—often sold as Chantix or Champix—can double your chances of quitting smoking compared with quitting cold turkey. It works by cutting cravings and making cigarettes less rewarding. That makes it one of the most effective prescription options, especially when combined with support or counseling.
Varenicline targets nicotine receptors in the brain. It partially activates those receptors to reduce withdrawal, but it also blocks nicotine’s full effect so cigarettes give less pleasure. Most people start a week before their planned quit day so the drug builds up in the body.
Typical dosing: 0.5 mg once daily for days 1–3, 0.5 mg twice daily for days 4–7, then 1 mg twice daily from day 8 onward. The usual course is 12 weeks; some people extend to 24 weeks if needed. If you have reduced kidney function, your doctor will lower the dose.
Take varenicline with food and a full glass of water to cut the chance of nausea. If nausea is a problem, try smaller meals and avoid fatty foods. Don’t stop suddenly without talking to your prescriber—there are plans to taper or switch treatments that might suit you.
Common side effects include nausea (the most frequent), vivid dreams or sleep disturbances, headache, constipation, and flatulence. These often ease after the first few weeks. Less common but serious issues are mood changes, anxiety, depression, or suicidal thoughts. If you or someone around you notices new or worsening mental health symptoms, stop the drug and contact your doctor right away.
Varenicline can interact with alcohol for some people—some report stronger intoxication or odd sleep-related behaviors. Use alcohol caution and watch for unusual reactions. It’s not advised in pregnancy or while breastfeeding unless a doctor says otherwise.
Only buy varenicline from a pharmacy that requires a prescription. Fake or cheap online sellers may ship counterfeit drugs that are ineffective or dangerous. Look for clear contact info, a licensed pharmacist you can speak to, and verified reviews. If an online site ships without a prescription, avoid it.
If varenicline isn’t right for you, other options exist: nicotine replacement (patches, gum), bupropion SR, and counseling. Combining medications with behavioral support gives the best result.
Quick tips that help: set a firm quit day, tell friends and family for support, plan alternatives for triggers (walk instead of smoke break), and keep a short list of coping actions (drink water, chew gum, step outside). Track progress—small wins matter.
Talk to your doctor about medical history, kidney function, and mental health before starting varenicline. Ask your pharmacist about dosing details and what to expect during the first few weeks. With the right plan, varenicline can be a powerful tool to stop smoking for good.
