Loperamide is a common over-the-counter anti-diarrheal. It slows gut movement by acting on opioid receptors in the intestines, which helps firm stools and reduce visits to the bathroom. Most people use it for acute, non-bloody diarrhea or for traveler's diarrhea when fluids and rest aren’t enough.
For adults, typical dosing starts with 4 mg (usually two 2 mg tablets), then 2 mg after each loose stool. Do not exceed 8 mg in a 24-hour period unless a doctor tells you otherwise. Some chronic conditions may require higher doses prescribed by a clinician, but you should never increase the OTC dose on your own.
For children and babies, follow label directions exactly and check with a pediatrician. Loperamide is not recommended for very young infants and should be used cautiously in young children; if a child shows dehydration, fever, or blood in stool, contact a doctor instead of treating at home.
Stop using loperamide and seek medical help if you have a high fever, bloody diarrhea, or signs of dehydration. Loperamide can mask infections like C. difficile and should not be used when an infectious cause with fever or blood is likely. If diarrhea follows recent antibiotics, call your doctor before taking loperamide.
Don’t mix loperamide with strong CYP3A4 or CYP2C8 inhibitors (for example, some antifungals and certain antivirals) without medical advice; such drugs can raise blood levels of loperamide. High doses of loperamide have been linked to serious heart rhythm problems, including QT prolongation and life-threatening arrhythmias. That risk rises dramatically when people misuse loperamide to try to relieve opioid withdrawal or take much more than recommended.
Common side effects are mild: constipation, dizziness, or belly cramps. If constipation is severe or you can’t pass gas, stop the drug and get medical care. Pregnant or breastfeeding people should check with their healthcare provider before use.
When to see a doctor: if diarrhea lasts more than 48 hours despite treatment, if you’re unable to drink enough fluids, or if you have severe abdominal pain, fever, or bloody stools.
Buying loperamide online: use licensed, reputable pharmacies. Check for clear contact info, a physical address, and pharmacy credentials. Avoid pharmacies that offer impossible discounts or don’t require a consult when a prescription is needed. Read reviews and look for secure checkout. If in doubt, ask your local pharmacist for a safe online option.
Bottom line: loperamide is effective for short-term control of non-bloody diarrhea when used exactly as directed. Respect dosing limits, watch for drug interactions, and get medical help for fever, blood in stool, or persistent symptoms.
