One course of isotretinoin can clear stubborn, scarring acne for years — but it’s not a casual choice. This medicine (often known by brand names like Accutane) is a vitamin A derivative that really cuts oil production and changes the skin environment. That’s why it works where many creams and antibiotics fail. But it also brings side effects and safety rules you can’t skip.
Isotretinoin shrinks oil glands, reduces clogged pores, and lowers inflammation. Doctors usually recommend it for severe nodular acne or acne that scars and doesn’t respond to other treatments. A typical treatment lasts several months and aims for a total cumulative dose that lowers the chance of relapse. Your prescriber will choose dose and schedule based on your skin, weight, and response.
Side effects are common and range from mild to serious. Expect dry lips, dry skin, and dry eyes — plan on a thick lip balm, gentle moisturizer, and artificial tears. You may get more sun-sensitive, so sunscreen matters. Less common but important effects include raised cholesterol or triglycerides, and liver enzyme changes. Your doctor will order blood tests before and during treatment to watch these.
Isotretinoin is highly teratogenic: it can cause severe birth defects. If you can get pregnant, you must use reliable contraception and take regular pregnancy tests before and during treatment. Many countries run strict pregnancy-prevention programs — follow them exactly.
Avoid extra vitamin A (including some supplements) while on isotretinoin. Don’t combine it with tetracycline antibiotics (risk of increased brain pressure), and limit alcohol because it stresses the liver and can raise triglycerides. Also don’t donate blood while taking isotretinoin and for a set time after stopping — check local rules.
Watch your mood. Some people report anxiety or depression while on isotretinoin. If you notice big mood changes, suicidal thoughts, or severe muscle weakness, contact your doctor right away. Don’t stop or start any psychiatric meds without discussing it with your prescriber.
Practical skincare during treatment: use a gentle, non-foaming cleanser, avoid scrubs and harsh peels, moisturize often, and skip waxing while skin is fragile. If you get severe joint pain, persistent headache, yellowing of the skin or eyes, or severe stomach pain, get medical help fast.
Finally, don’t buy isotretinoin from unreliable online sellers without a prescription. Insist on a licensed pharmacy and a prescriber who will monitor you. The drug works, but its safety plan is part of the treatment — follow it and keep in regular contact with your healthcare team.
