When it comes to erectile dysfunction treatment, medications that help men get and keep an erection by increasing blood flow to the penis. Also known as ED pills, these drugs are among the most commonly prescribed for men over 40, but not all are created equal. You might have heard of Viagra, Cialis, or Levitra—but knowing the difference isn’t just about brand names. It’s about how long they last, how fast they kick in, what they cost, and which one actually fits your life.
Take sildenafil, the first widely used ED medication, sold as Viagra and many generics. Also known as Viagra, it starts working in about 30 to 60 minutes and lasts 4 to 5 hours. If you’re planning a night out, it works fine—but you need to time it right and avoid heavy meals. Then there’s tadalafil, the long-acting option sold as Cialis. Also known as Cialis, it can last up to 36 hours, which is why some call it the "weekend pill." That means less planning, more spontaneity. But it also means side effects like back pain or muscle aches might stick around longer. And then there’s vardenafil, a middle-ground drug sold as Levitra and Staxyn. Also known as Levitra, it works faster than sildenafil for some men and has fewer food interactions. Each one has different side effects: headaches, flushing, stuffy nose, or upset stomach. Some men find one works better than the others simply because their body responds differently.
It’s not just about the pill. Your health matters too. If you have heart problems, high blood pressure, or take nitrates for chest pain, some ED meds can be dangerous. Even if you’re healthy, your doctor might suggest starting low and going slow. And if one doesn’t work, it doesn’t mean they all won’t. Many men try two or three before finding the right fit. You’re not alone in this. Thousands of men switch between these drugs based on how they feel that day, what they ate, or even stress levels.
Below, you’ll find real comparisons—not marketing fluff. We’ve pulled together posts that break down how these drugs stack up against each other, what alternatives exist, and how other men made their choices. Whether you’re new to this or have been using one for years, there’s something here that’ll help you make a smarter, more confident decision.
